Niacinamide and Vitamic: Can You Layer Them Together?

Can You Use Niacinamide and Vitamin C Together?

A regular and optimal skin care regimen contributes to enhancing your skin's health, thus appearance. Niacinamide and vitamin C are two well-liked ingredients that may provide a variety of complementary benefits, from reducing inflammation to reducing wrinkles on your skin. But can you use Niacinamide with vitamin C?

Using both products can be a good idea if you've come across outdated advice that says you should avoid mixing them. The good news is that you can combine Niacinamide-containing products in your skincare with vitamin C-containing products.

If myth is to be believed, then their combination neutralises the benefits of both. That’s not true!

Here are the specifics on what each component does for the skin and advice on how to use them successfully in your skincare routine.

Niacinamide: The Benefits

Niacinamide, sometimes referred to as vitamin B3 and Nicotinamide is a versatile substance essential for maintaining healthy skin.

Due to its water-soluble nature, and ability to normalise the lining of pores and diminish the appearance of stretched pores, and dark spots, it is frequently used as a supplement with practical benefits, such as:

  • Improved hydration.
  • Reduced hyperpigmentation.
  • Support against ageing.
  • Shrunken pore appearance.
  • Reduced acne.
  • Reduced facial redness.

Enhance your skincare routine with our comprehensive guide on Niacinamide for the skin today! 

Vitamin C: The Benefits

An antioxidant with scientific support, vitamin C aids in keeping skin tone and appearance even and youthful. It functions well when used under broad-spectrum sunscreen and in combination with other antioxidants, especially vitamin E. Vitamin C is a sensitive substance susceptible to deterioration when exposed to air and light. Look for vitamin C goods with airtight and light-protective packaging when shopping. It has numerous more skin-friendly properties.

  • Offers pro-aging support.
  • Brightens skin.
  • Reduces inflammation.
  • Diminishes the appearance of scars.

Myths and Facts About Niacinamide and Vitamin C 

Niacinamide is a somewhat potent substance; unlike antioxidants like vitamin C, it is less affected by light and air. The product's formulation at a nearly neutral pH is crucial for Niacinamide.

On the other hand, pure ascorbic acid, or vitamin C, thrives in an acidic, low-pH environment. Niacinamide and vitamin C only produce the unwanted by-product nicotinic acid when mixed for a lengthy period in a high-temperature setting.

That temperature is higher than you'd typically encounter at home, such as leaving a box of skin care products in the sun for a few days.

It's also pivotal to note that this worry only pertains to pure vitamin C and not any of its numerous other forms, including ascorbyl glucoside, tetrahexyldecyl ascorbate, and magnesium ascorbyl phosphate.

Combining Niacinamide and pure vitamin C (ascorbic or l-ascorbic acid) is all right, as daily applications of these potent components do not include the conditions that result in nicotinic acid.

Benefits of Mixing Niacinamide with Vitamin C

Skin that bears Niacinamide can noticeably reduce the look of wrinkles, enlarged pores, and lacklustre, while vitamin C protects it from environmental stresses and minimises dullness as a powerful antioxidant. It further lessens the signs of ageing.

These components may work as a potent team to combat uneven skin tone, wrinkles, dullness, and loss of firmness. You will see a complexion that gradually gets visibly younger-looking, luminous, more even, and smoother, regardless of whether you have sensitive, oily, combination, or dry skin.

So, combining Niacinamide and vitamin C is safe and is likely to revitalise the skin’s appearance.

How to Layer Them?

While the combination of Niacinamide and vitamin C used to be an inappropriate pair, this belief has now outdated with the latest research and developments in skin care studies.

In fact, they are used as a power pair to let you avail of various benefits at once, adding to skin health.

First, cleanse your skin properly and let it dry. Then apply vitamin C serum and go for your chosen Niacinamide product. This is what the common practice suggests.

There is no universal way of layering them. You must take a skincare expert’s advice as the way of layering changes with the skin and product’s formulations. For optimal absorption, you can apply the “thinnest to thickest” idea as a rule of thumb to maximise results.

While the combination can be used twice a day, the best times to use a vitamin C serum are both morning and night.

  • When used in the morning: Prevents oxidative stress on the skin caused by pollutants.
  • When used at night: Restore the depleted vitamin C concentration caused by solar radiation.

Potential Side Effects, If Any:

Even if skin care products contain ingredients like vitamin C and Niacinamide, your skin may not react well.

This is why it's safe to perform a patch test and watch out for any indications of a possible adverse reaction. The most frequent adverse reaction to Niacinamide and vitamin C is skin inflammation.

Any redness, discolouration, itching, or stinging during the patch test indicates that the product won't get along with your skin. It is advised to cease using a skincare or beauty product immediately and consult a dermatologist before using it again if you have irritation after using it.

Radiance 3D - 10% Niacinamide serum

DRSQ’s Radiance 3D contains 10% Niacinamide (vitamin B3) and hyaluronic acid. It may benefit your skin by reducing congestion, pigmentation, and facial redness and promoting skin clarity, brightness, and vitality.

It is a potent boosting radiance serum that comes with anti-inflammatory and antioxidant benefits. You may find it driving helpful results in preventing hyperpigmentation and acne scars, leading to more rejuvenated and younger-looking skin.


Niacinamide and vitamin C can be combined, having numerous skin-friendly properties. However, it's best to conduct a patch test beforehand. A dermatologist should always be consulted before adopting a new skincare regimen. It will help you so you don’t end up cancelling the benefits of the products.


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